News: Journal Watch

New prostate cancer treatment concept Prostate cancer, the second leading cause of cancer-related death for men in the United States, is poorly responsive to immunotherapy. Recent clinical trials have hinted that combining immunotherapy and radiation therapy may be a powerful treatment approach for castration-resistant prostate cancer. Austin Kirschner, MD, PhD, and colleagues combined radiotherapy with […]

Cancer prevention drug also disables H. pylori bacterium A medicine currently being tested as a chemoprevention agent for multiple types of cancer has more than one trick in its bag when it comes to preventing stomach cancer. Keith Wilson, MD, and J. Carolina Sierra, PhD, reported in the March 12 issue of Proceedings of the […]

Glutamine metabolism affects T cell signaling & function The cellular nutrient glutamine launches a metabolic signaling pathway that promotes the function of some immune system T cells and suppresses others, Vanderbilt researchers have discovered. They show that a drug that inhibits glutamine metabolism — currently in clinical trials as an anticancer agent — might also […]

Novel anti-cancer drug resistance mechanism identified Vanderbilt investigators have discovered a novel nongenetic cause of resistance to cetuximab, a mainstay of treatment for advanced colorectal cancer. The findings of Robert Coffey Jr., MD, and colleagues, published Oct. 16, 2017, in Nature Medicine, suggest a strategy for overcoming this resistance, which their research indicates is due […]

New target for colorectal cancer  In a study published March 6 in the journal Oncogene, Dana Hardbower, Ph.D., Keith Wilson, M.D., and colleagues demonstrated that epidermal growth factor receptor (EGFR) signaling in macrophages is associated with increased colitis-associated colon cancer development. While inflammatory bowel disease and colitis can increase the risk of colon cancer, the […]

Discovery offers new insight on lung cancer risk Researchers have discovered a proteomic “signature” from the airways of heavy smokers that could lead to better risk assessment and perhaps new ways to stop lung cancer before it starts. The findings, reported Nov. 17, 2016, in JCI Insight, are based on the observation that otherwise normal-looking […]

VUMC study: current cancer drug discovery method flawed The primary method used to test compounds for anti-cancer activity in cells is flawed, Vito Quaranta, M.D., and colleagues reported May 2 in Nature Methods. The scientists developed a new metric to evaluate a compound’s effect on cell proliferation. The old system counted how many cancer cells […]

Study identifies new culprit in lung cancer development A microRNA—a small piece of RNA involved in regulating gene expression—functions as an oncogene to drive the development of lung cancer, Vanderbilt-Ingram Cancer Center investigators have discovered. The microRNA, known as miR-31, is expressed at high levels in human lung adenocarcinoma, and its expression correlates with reduced […]

Protein identified as potential target for lung cancer treatment A protein that transports the amino acid glutamine is a potential biomarker and therapeutic target for non-small cell lung cancer, Vanderbilt-Ingram Cancer Center researchers reported in the Oct. 1, 2015, International Journal of Cancer. Pierre Massion, M.D., Cornelius Vanderbilt Chair in Medicine, and colleagues demonstrated that […]

Vanderbilt-Ingram Cancer Center is committed to conducting innovative, high-impact, basic, translational and clinical research with the greatest potential for making a difference for cancer patients, today and in the future. Here’s a sampling of work published in peer-reviewed journals by Cancer Center investigators in 2014-2015:   Study in East Asians identifies genes tied to colon […]